CeO<sub>2</sub>-Azacrown Conjugate as a Nanoplatform for Combined Radiopharmaceuticals

Sofia Khabirova; Gleb Aleshin; Tatiana Plakhova; Anastasia Zubenko; Anna Shchukina; Olga Fedorova; Aleksey Averin; Ekaterina Belova; Elena Bazarkina; Kristina Kvashnina; Stepan Kalmykov

doi:10.3390/nano12244484

Nanomaterials (Dec 2022)

CeO<sub>2</sub>-Azacrown Conjugate as a Nanoplatform for Combined Radiopharmaceuticals

Sofia Khabirova,
Gleb Aleshin,
Tatiana Plakhova,
Anastasia Zubenko,
Anna Shchukina,
Olga Fedorova,
Aleksey Averin,
Ekaterina Belova,
Elena Bazarkina,
Kristina Kvashnina,
Stepan Kalmykov

Affiliations

Sofia Khabirova: Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Gleb Aleshin: Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Tatiana Plakhova: Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Anastasia Zubenko: N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia
Anna Shchukina: N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia
Olga Fedorova: N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia
Aleksey Averin: Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences, Leninskiy Ave. 31b4, 119991 Moscow, Russia
Ekaterina Belova: Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Elena Bazarkina: The Rossendorf Beamline at ESRF—The European Synchrotron, CS40220, CEDEX 9, 38043 Grenoble, France
Kristina Kvashnina: The Rossendorf Beamline at ESRF—The European Synchrotron, CS40220, CEDEX 9, 38043 Grenoble, France
Stepan Kalmykov: Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia

DOI: https://doi.org/10.3390/nano12244484
Journal volume & issue: Vol. 12, no. 24
p. 4484

Abstract

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This study is one of the first attempts to assess CeO2 nanoparticles as a nanoplatform for radiopharmaceuticals with radionuclides. The process of functionalization using a bifunctional azacrown ligand is described, and the resulting conjugates are characterized by IR and Raman spectroscopy. Their complexes with 207Bi show a high stability in medically relevant media, thus encouraging the further study of these conjugates in vivo as potential combined radiopharmaceuticals.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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