Pathophysiological aspects of blood transfusion for patients with liver cirrhosis

Abstract

To date, there are no clear indications and reasons for transfusion therapy in patients with cirrhosis. The article discusses the basic pathophysiological changes in the patient’s body during the formation of the liver cirrhosis as the outcome of hepatitis of different etiology. Particular attention is given to a component of donor plasma fibronectin, the lack of which, including in patients with liver cirrhosis, causes progressing endotoxemia.

Keywords

• liver cirrhosis
• endotoxin
• endotoxemia
• kupfer cells
• fibronectin
• anemia
• coagulopathy
• thrombocytopenia