Nature Communications (Oct 2019)
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
- Charlotte Rimbault,
- Kashyap Maruthi,
- Christelle Breillat,
- Camille Genuer,
- Sara Crespillo,
- Virginia Puente-Muñoz,
- Ingrid Chamma,
- Isabel Gauthereau,
- Ségolène Antoine,
- Coraline Thibaut,
- Fabienne Wong Jun Tai,
- Benjamin Dartigues,
- Dolors Grillo-Bosch,
- Stéphane Claverol,
- Christel Poujol,
- Daniel Choquet,
- Cameron D. Mackereth,
- Matthieu Sainlos
Affiliations
- Charlotte Rimbault
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Kashyap Maruthi
- Institut Européen de Chimie et Biologie, Univ. Bordeaux
- Christelle Breillat
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Camille Genuer
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Sara Crespillo
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Virginia Puente-Muñoz
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Ingrid Chamma
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Isabel Gauthereau
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Ségolène Antoine
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Coraline Thibaut
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Fabienne Wong Jun Tai
- University of Bordeaux, CBiB-LaBRI
- Benjamin Dartigues
- University of Bordeaux, CBiB-LaBRI
- Dolors Grillo-Bosch
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Stéphane Claverol
- Proteome Platform, Functional Genomic Center of Bordeaux, University of Bordeaux
- Christel Poujol
- Bordeaux Imaging Center, UMS 3420 Centre National de la Recherche Scientifique, University of Bordeaux, US 4 INSERM
- Daniel Choquet
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- Cameron D. Mackereth
- Institut Européen de Chimie et Biologie, Univ. Bordeaux
- Matthieu Sainlos
- Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique
- DOI
- https://doi.org/10.1038/s41467-019-12528-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 20
Abstract
Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and create a paralog-selective PSD-95 inhibitor as proof-of-concept.
