A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division

Abstract

Owa and Dynlacht employ an auxin-inducible degron system to achieve acute degradation of CENP-E. As a result, the authors reveal a kinetochore-independent role for CENP-E that removes PCM1 from centrosomes in interphase, with implications in microcephaly.