Nature Communications (Oct 2016)
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
- Jianzhao Liu,
- Yuanxiang Zhu,
- Guan-Zheng Luo,
- Xinxia Wang,
- Yanan Yue,
- Xiaona Wang,
- Xin Zong,
- Kai Chen,
- Hang Yin,
- Ye Fu,
- Dali Han,
- Yizhen Wang,
- Dahua Chen,
- Chuan He
Affiliations
- Jianzhao Liu
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Yuanxiang Zhu
- State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
- Guan-Zheng Luo
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Xinxia Wang
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Yanan Yue
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Xiaona Wang
- State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
- Xin Zong
- Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University
- Kai Chen
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Hang Yin
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Ye Fu
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Dali Han
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Yizhen Wang
- Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University
- Dahua Chen
- State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
- Chuan He
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- DOI
- https://doi.org/10.1038/ncomms13052
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 7
Abstract
DNA 6mA is a poorly understood epigenetic mark present at a low abundance in eukaryotic genomes. Here the authors observe high levels in zebrafish and pig during early embryogenesis enriched to repetitive regions of the genome and followed by attenuation during development.
