Communications Biology (Feb 2022)

Abacavir inhibits but does not cause self-reactivity to HLA-B*57:01-restricted EBV specific T cell receptors

  • Anuradha Sooda,
  • Francois Rwandamuriye,
  • Celestine N. Wanjalla,
  • Lichen Jing,
  • David M. Koelle,
  • Bjoern Peters,
  • Shay Leary,
  • Abha Chopra,
  • Michael A. Calderwood,
  • Simon A. Mallal,
  • Rebecca Pavlos,
  • Mark Watson,
  • Elizabeth J. Phillips,
  • Alec J. Redwood

DOI
https://doi.org/10.1038/s42003-022-03058-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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HLA-B*57:01 restricted EBV-specific T-cell receptor specificity is altered by abacavir, suggesting a potentially inhibitory effect of abacavir on HLA-B*57:01 restricted TCR recognition.