Fibrous hydrogels under biaxial confinement

Yang Li; Yunfeng Li; Elisabeth Prince; Jeffrey I. Weitz; Sergey Panyukov; Arun Ramachandran; Michael Rubinstein; Eugenia Kumacheva

doi:10.1038/s41467-022-30980-7

Nature Communications (Jun 2022)

Fibrous hydrogels under biaxial confinement

Yang Li,
Yunfeng Li,
Elisabeth Prince,
Jeffrey I. Weitz,
Sergey Panyukov,
Arun Ramachandran,
Michael Rubinstein,
Eugenia Kumacheva

Affiliations

Yang Li: Department of Chemical Engineering & Applied Chemistry, University of Toronto
Yunfeng Li: Department of Chemistry, University of Toronto
Elisabeth Prince: Department of Chemistry, University of Toronto
Jeffrey I. Weitz: Thrombosis and Atherosclerosis Research Institute
Sergey Panyukov: P. N. Lebedev Physics Institute, Russian Academy of Sciences
Arun Ramachandran: Department of Chemical Engineering & Applied Chemistry, University of Toronto
Michael Rubinstein: Department of Mechanical Engineering and Materials Science, Duke University
Eugenia Kumacheva: Department of Chemical Engineering & Applied Chemistry, University of Toronto

DOI: https://doi.org/10.1038/s41467-022-30980-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 6

Abstract

Read online

Studies of the confinement of filamentous hydrogels such as fibrin, a major component of blood clots, can shed light on the resistance of strained occlusive clots to lysis with therapeutic agents. Here, the authors show the mechanism of the response of fibrous hydrogels to confinement.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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