Stem Cell Research (Dec 2021)
Construction of induced pluripotent stem cell line (ZZUi031-A) of a healthy young Chinese Han male
- Shaohua Li,
- Yunchao Wang,
- Huifang Sun,
- Zhuoya Wang,
- Qi Zhang,
- Yanlin Wang,
- Jing Yang,
- Changhe Shi,
- Yanpeng Yuan,
- Hao Wang,
- Liyuan Fan,
- Zhuo Li,
- Yuming Xu
Affiliations
- Shaohua Li
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China; Academy of Medical Sciences of Zhengzhou University Translational Medicine Platform, Zhengzhou 450000, Henan, China
- Yunchao Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
- Huifang Sun
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
- Zhuoya Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
- Qi Zhang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China; Academy of Medical Sciences of Zhengzhou University Translational Medicine Platform, Zhengzhou 450000, Henan, China
- Yanlin Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
- Jing Yang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
- Changhe Shi
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
- Yanpeng Yuan
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
- Hao Wang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China; Academy of Medical Sciences of Zhengzhou University Translational Medicine Platform, Zhengzhou 450000, Henan, China
- Liyuan Fan
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China; Academy of Medical Sciences of Zhengzhou University Translational Medicine Platform, Zhengzhou 450000, Henan, China
- Zhuo Li
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Corresponding authors at: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China.
- Yuming Xu
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China; Corresponding authors at: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China.
- Journal volume & issue
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Vol. 57
p. 102608
Abstract
We have successively constructed several induced pluripotent stem cell (iPSC) lines of middle-aged and elderly male, but cell samples from young donors are still scarce. In this project, we recruited a healthy 29-year-old Chinese Han male, obtained his skin fibroblasts and successfully established iPSC line using non-integrated reprogramming technology. The iPSC line showed normal karyotype, expressed pluripotency markers and differentiated into three germ layers in vivo. The cell line will serve as an available control in the research of pathological mechanisms of early-onset neurological diseases.
