Nature Communications (Feb 2019)
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
- Marilia Rita Pinzone,
- D. Jake VanBelzen,
- Sam Weissman,
- Maria Paola Bertuccio,
- LaMont Cannon,
- Emmanuele Venanzi-Rullo,
- Stephen Migueles,
- R. Brad Jones,
- Talia Mota,
- Sarah B. Joseph,
- Kevin Groen,
- Alexander O. Pasternak,
- Wei-Ting Hwang,
- Brad Sherman,
- Anastasios Vourekas,
- Giuseppe Nunnari,
- Una O’Doherty
Affiliations
- Marilia Rita Pinzone
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- D. Jake VanBelzen
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Sam Weissman
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Maria Paola Bertuccio
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- LaMont Cannon
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Emmanuele Venanzi-Rullo
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Stephen Migueles
- Laboratory of Immunoregulation, National Institutes of Allergy & Infectious Diseases, National Institutes of Health
- R. Brad Jones
- Infectious Disease Division, Weill Cornell Medical College
- Talia Mota
- Infectious Disease Division, Weill Cornell Medical College
- Sarah B. Joseph
- Department of Microbiology and Immunology, University of North Carolina at Chapel Hill
- Kevin Groen
- Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam
- Alexander O. Pasternak
- Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam
- Wei-Ting Hwang
- Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania
- Brad Sherman
- Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratories for Cancer Research, Leidos Biomedical Research Inc., supporting the Division of Clinical Research, NIAID
- Anastasios Vourekas
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Giuseppe Nunnari
- Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina
- Una O’Doherty
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-019-08431-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.
