Nature Communications (Mar 2022)
GIT1 protects against breast cancer growth through negative regulation of Notch
- Songbai Zhang,
- Ayako Miyakawa,
- Malin Wickström,
- Cecilia Dyberg,
- Lauri Louhivuori,
- Manuel Varas-Godoy,
- Kati Kemppainen,
- Shigeaki Kanatani,
- Dagmara Kaczynska,
- Ivar Dehnisch Ellström,
- Lotta Elfman,
- Pauliina Kronqvist,
- Heli Repo,
- Katsuhiko Mikoshiba,
- Cecilia Sahlgren,
- John Inge Johnsen,
- Per Uhlén
Affiliations
- Songbai Zhang
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Ayako Miyakawa
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Malin Wickström
- Department of Women’s and Children’s Health, Karolinska Institutet
- Cecilia Dyberg
- Department of Women’s and Children’s Health, Karolinska Institutet
- Lauri Louhivuori
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Manuel Varas-Godoy
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Kati Kemppainen
- Turku Bioscience, Åbo Akademi University and University of Turku
- Shigeaki Kanatani
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Dagmara Kaczynska
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Ivar Dehnisch Ellström
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Lotta Elfman
- Department of Women’s and Children’s Health, Karolinska Institutet
- Pauliina Kronqvist
- Department of Pathology, University of Turku
- Heli Repo
- Department of Pathology, University of Turku
- Katsuhiko Mikoshiba
- Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
- Cecilia Sahlgren
- Turku Bioscience, Åbo Akademi University and University of Turku
- John Inge Johnsen
- Department of Women’s and Children’s Health, Karolinska Institutet
- Per Uhlén
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-022-28631-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in ER- breast cancer by blocking Notch ICD nuclear translocation.
