Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters

Abstract

A copper-catalyzed cascade reaction of α,β-unsaturated esters with keto esters is reported. It features a copper-catalyzed reductive aldolization followed by a lactonization. This method provides a facile approach to prepare γ-carboxymethyl-γ-lactones and δ-carboxymethyl-δ-lactones under mild reaction conditions.

Keywords

• aldol addition
• cascade reaction
• catalysis
• conjugate reduction
• copper
• lactonization