Regulatory mechanisms of incomplete huntingtin mRNA splicing

Andreas Neueder; Anaelle A. Dumas; Agnesska C. Benjamin; Gillian P. Bates

doi:10.1038/s41467-018-06281-3

Nature Communications (Sep 2018)

Regulatory mechanisms of incomplete huntingtin mRNA splicing

Andreas Neueder,
Anaelle A. Dumas,
Agnesska C. Benjamin,
Gillian P. Bates

Affiliations

Andreas Neueder: UCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College London
Anaelle A. Dumas: UCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College London
Agnesska C. Benjamin: UCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College London
Gillian P. Bates: UCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College London

DOI: https://doi.org/10.1038/s41467-018-06281-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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