Determination of Platelet Count and Platelet Indices among Sudanese Patients with Chronic Kidney Disease

Abstract

Background: Patients with chronic kidney disease (CKD) are at a considerably higher risk of thrombotic and hemorrhagic challenges. Platelet function studies in CKD are contradictory, ranging from decreased platelet function to normal or even increased platelet reaction. Our study aims to evaluate the change in platelet count (PC) and platelet indices (platelet distribution width [PDW], platelet large cell ratio [PLCR], and mean platelet volume [MPV]) among Sudanese patients with CKD. Methods and Results: This case-control study was conducted from February to August 2014 at East Nile Hospital, Khartoum, Sudan. The study involved 75 patients diagnosed with CKD (mean age 52.43±18.4 years) and 75 healthy individuals (mean age 50.3±14 years) as a control group. PC, PDW, PLCR, and MPV tests were conducted using a Sysmex KX-21N Automated Hematology Analyzer (Sysmex Corporation, Japan), and creatinine level was measured by Roche/Hitachi Cobas C311 analyzer (Basel Switzerland). The creatinine level was significantly higher in CKD patients than in the control group: 7.91±4.8 mg/dL and 1.4±1.3mg/dL, respectively (P=0.000). We found an insignificant difference between CKD patients and the control group in terms of PC, MPV, PDW, and PLCR; an insignificant difference in PC and all PI between CKD patients with creatinine levels 6mg/dL; and an insignificant difference in PC and all PI between the group with CKD duration 2 years and between CKD patients on hemodialysis and without hemodialysis. Conclusion: This study found no difference in PC and studied platelet indices in CKD patients, compared to the control group and no difference in PC and PI (MPV, PDW, and PLCR) in patients on hemodialysis versus patients not on hemodialysis.

Keywords

• chronic kidney disease
• platelet count
• platelet indices
• hemodialysis