Comparing Hydroxypropyl Methylcellulose and Guar Gum on Sustained Release Effect of Metformin Hydrochloride Matrix Tablet

Abstract

Background and Objectives: Limited diabetes drug availability and frequent adverse reactions to oral medications highlight the need for improved drug delivery. This study suggests optimizing drug efficiency through process modifications, focusing on anti-diabetic medications like metformin hydrochloride. Matrix-type formulations are utilized to overcome current drug targeting and dosage management limitations. Methods: This study aims to improve anti-diabetic drugs, focusing on metformin hydrochloride, via process modifications in drug delivery. We developed a sustainable drug release process with matrix-type formulations, comparing hydroxyl propyl methylcellulose (HPMC) and guar gum as rate-controlling polymers. The optimized formulation was then compared with Glyciphage SR 500 to identify similarities and differences in drug release profiles. Results: We utilized matrix-type formulations to administer metformin hydrochloride. It develops a sustainable drug release process with HPMC and guar gum as rate-controlling polymers. Next, we conducted comparative drug release studies, systematically optimized the formulation, and compared it to Glyciphage SR 500 using appropriate analytical methods. Results: Comparative dissolution data, including a high similarity factor (f2) of 75.33 with Glyciphage SR 500, emphasizes the promising resemblance between metformin hydrochloride tablet (MT5) and the market sample, warranting further stability studies for potential upscaling. Conclusion: The study's novelty lies in successfully formulating sustained-release MT5 using HPMC K100M and guar gum via wet granulation, demonstrating a potential reduction in dosing frequency and adverse effects. MT5's optimal physical and chemical parameters and sustained drug release exceeded 99% at 12 hours.

Keywords

• in vitro techniques
• metformin
• polymers
• sustained release formulation
• tablets