Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid

Keisuke Sato; Kyoko Yamazaki; Tamotsu Kato; Yumiko Nakanishi; Takahiro Tsuzuno; Mai Yokoji-Takeuchi; Miki Yamada-Hara; Nobuaki Miura; Shujiro Okuda; Hiroshi Ohno; Kazuhisa Yamazaki

doi:10.1128/mBio.00771-21

mBio (Jun 2021)

Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid

Keisuke Sato,
Kyoko Yamazaki,
Tamotsu Kato,
Yumiko Nakanishi,
Takahiro Tsuzuno,
Mai Yokoji-Takeuchi,
Miki Yamada-Hara,
Nobuaki Miura,
Shujiro Okuda,
Hiroshi Ohno,
Kazuhisa Yamazaki

Affiliations

Keisuke Sato: Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Kyoko Yamazaki: Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Tamotsu Kato: Laboratory for Intestinal Ecosystem, RIKEN Centre for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan
Yumiko Nakanishi: Laboratory for Intestinal Ecosystem, RIKEN Centre for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan
Takahiro Tsuzuno: Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Mai Yokoji-Takeuchi: Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Miki Yamada-Hara: Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Nobuaki Miura: Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Shujiro Okuda: Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan
Hiroshi Ohno: Laboratory for Intestinal Ecosystem, RIKEN Centre for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan
Kazuhisa Yamazaki: ORCiD; Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan

DOI: https://doi.org/10.1128/mBio.00771-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Obesity is an epidemic health issue with a rapid increase worldwide. It increases the risk of various diseases, including periodontal disease, an oral chronic infectious disease.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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