Nature Communications (Sep 2022)
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia
- Seung Hyun Lee,
- Nayoung Kim,
- Minkyu Kim,
- Sang-Ho Woo,
- Inhee Han,
- Jisu Park,
- Kyeongdae Kim,
- Kyu Seong Park,
- Kibyeong Kim,
- Dahee Shim,
- Sang-eun Park,
- Jing Yu Zhang,
- Du-Min Go,
- Dae-Yong Kim,
- Won Kee Yoon,
- Seung-Pyo Lee,
- Jongsuk Chung,
- Ki-Wook Kim,
- Jung Hwan Park,
- Seung Hyun Lee,
- Sak Lee,
- Soo-jin Ann,
- Sang-Hak Lee,
- Hyo-Suk Ahn,
- Seong Cheol Jeong,
- Tae Kyeong Kim,
- Goo Taeg Oh,
- Woong-Yang Park,
- Hae-Ock Lee,
- Jae-Hoon Choi
Affiliations
- Seung Hyun Lee
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Nayoung Kim
- Department of Microbiology, College of Medicine, The Catholic University of Korea
- Minkyu Kim
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Sang-Ho Woo
- Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University
- Inhee Han
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Jisu Park
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Kyeongdae Kim
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Kyu Seong Park
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Kibyeong Kim
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Dahee Shim
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Sang-eun Park
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Jing Yu Zhang
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- Du-Min Go
- Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University
- Dae-Yong Kim
- Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University
- Won Kee Yoon
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Seung-Pyo Lee
- Cardiovascular Center and Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine
- Jongsuk Chung
- Samsung Genome Institute, Samsung Medical Center
- Ki-Wook Kim
- Department of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine
- Jung Hwan Park
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University College of Medicine
- Seung Hyun Lee
- Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine
- Sak Lee
- Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine
- Soo-jin Ann
- Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine
- Sang-Hak Lee
- Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine
- Hyo-Suk Ahn
- Division of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
- Seong Cheol Jeong
- Department of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
- Tae Kyeong Kim
- Heart-Immune-Brain Network Research Center, Department of Life Science, Ewha Womans University
- Goo Taeg Oh
- Heart-Immune-Brain Network Research Center, Department of Life Science, Ewha Womans University
- Woong-Yang Park
- Samsung Genome Institute, Samsung Medical Center
- Hae-Ock Lee
- Department of Microbiology, College of Medicine, The Catholic University of Korea
- Jae-Hoon Choi
- Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University
- DOI
- https://doi.org/10.1038/s41467-022-33202-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Identifying the mechanisms underlying the early inflammatory phase of aortic valve disease is crucial for disease prevention. Here the authors perform single-cell RNA sequencing to show the immunomodulatory role of PPARγ in valvular endothelial cells during hyperlipidemia.
