Nature Communications (Mar 2021)
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
- András Maifeld,
- Hendrik Bartolomaeus,
- Ulrike Löber,
- Ellen G. Avery,
- Nico Steckhan,
- Lajos Markó,
- Nicola Wilck,
- Ibrahim Hamad,
- Urša Šušnjar,
- Anja Mähler,
- Christoph Hohmann,
- Chia-Yu Chen,
- Holger Cramer,
- Gustav Dobos,
- Till Robin Lesker,
- Till Strowig,
- Ralf Dechend,
- Danilo Bzdok,
- Markus Kleinewietfeld,
- Andreas Michalsen,
- Dominik N. Müller,
- Sofia K. Forslund
Affiliations
- András Maifeld
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Hendrik Bartolomaeus
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Ulrike Löber
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Ellen G. Avery
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Nico Steckhan
- Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Lajos Markó
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Nicola Wilck
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Ibrahim Hamad
- VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), UHasselt, Campus Diepenbeek
- Urša Šušnjar
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Anja Mähler
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Christoph Hohmann
- Department of Internal and Integrative Medicine, Immanuel Krankenhaus Berlin
- Chia-Yu Chen
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Holger Cramer
- Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen
- Gustav Dobos
- Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen
- Till Robin Lesker
- Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research
- Till Strowig
- Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research
- Ralf Dechend
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Danilo Bzdok
- Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, McGill University
- Markus Kleinewietfeld
- VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), UHasselt, Campus Diepenbeek
- Andreas Michalsen
- Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Dominik N. Müller
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Sofia K. Forslund
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- DOI
- https://doi.org/10.1038/s41467-021-22097-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Nutritional modification including fasting has been shown to reduce cardiometabolic risk linked to western diet. Here the authors show implementation of fasting resulted in alterations to the intestinal microbiota, and circulating immune cells, improving blood pressure and body weight in patients with metabolic syndrome.
