Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43

Ying Chen; Ying Chen; Huazhong Liu; Hao Huang; Yuetang Ma; Ruihua Wang; Yong Hu; Xiufen Zheng; Chunmei Chen; Hongfeng Tang

doi:10.3389/fphar.2019.01574

Frontiers in Pharmacology (Jan 2020)

Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43

Ying Chen,
Ying Chen,
Huazhong Liu,
Hao Huang,
Yuetang Ma,
Ruihua Wang,
Yong Hu,
Xiufen Zheng,
Chunmei Chen,
Hongfeng Tang

Affiliations

Ying Chen: Department of Dermatology, Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College, Nanchong, China
Ying Chen: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Huazhong Liu: College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, China
Hao Huang: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Yuetang Ma: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Ruihua Wang: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Yong Hu: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Xiufen Zheng: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Chunmei Chen: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China
Hongfeng Tang: Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, China

DOI: https://doi.org/10.3389/fphar.2019.01574
Journal volume & issue: Vol. 10

Abstract

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Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H2O2-induced dermal fibroblast damage. Our results show that squid ink polysaccharides effectively reduce the fibroblast oxidative damage mediated by the up-regulation of NADPH oxidase and Connexin43. Concurrently, squid ink polysaccharides decrease the ROS induced up-regulation of MMP1 and MMP9 to decrease MMP-mediated skin aging. Therefore, we hypothesize that squid ink polysaccharides play an antioxidant role by inhibiting the expression of NADPH oxidase and connexin43. This provides a new target for the effective clinical prevention and treatment of oxidative skin damage.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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