Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

Haithem Barbour; Salima Daou; Michael Hendzel; El Bachir Affar

doi:10.1038/s41467-020-19722-9

Nature Communications (Nov 2020)

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

Haithem Barbour,
Salima Daou,
Michael Hendzel,
El Bachir Affar

Affiliations

Haithem Barbour: Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
Salima Daou: Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
Michael Hendzel: Departments of Oncology and Cell Biology, University of Alberta, Room 3332 Cross Cancer Institute, 11560 University Avenue NW
El Bachir Affar: Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal

DOI: https://doi.org/10.1038/s41467-020-19722-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Histone H2A monoubiquitination on lysine 119 in vertebrate and lysine 118 in Drosophila (H2Aub) is an epigenomic mark usually associated with gene repression by Polycomb group factors. Here the authors review the current knowledge on the deposition and removal of H2Aub, its function in transcription and other DNA-associated processes as well as its relevance to human disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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