Nature Communications (Jun 2019)

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

  • Dieter Henrik Heiland,
  • Vidhya M. Ravi,
  • Simon P. Behringer,
  • Jan Hendrik Frenking,
  • Julian Wurm,
  • Kevin Joseph,
  • Nicklas W. C. Garrelfs,
  • Jakob Strähle,
  • Sabrina Heynckes,
  • Jürgen Grauvogel,
  • Pamela Franco,
  • Irina Mader,
  • Matthias Schneider,
  • Anna-Laura Potthoff,
  • Daniel Delev,
  • Ulrich G. Hofmann,
  • Christian Fung,
  • Jürgen Beck,
  • Roman Sankowski,
  • Marco Prinz,
  • Oliver Schnell

DOI
https://doi.org/10.1038/s41467-019-10493-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.