A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Christopher Thomas; Benjamin Wetherall; Mark D. Levasseur; Rebecca J. Harris; Scott T. Kerridge; Jonathan M. G. Higgins; Owen R. Davies; Suzanne Madgwick

doi:10.1038/s41467-021-24554-2

Nature Communications (Jul 2021)

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Christopher Thomas,
Benjamin Wetherall,
Mark D. Levasseur,
Rebecca J. Harris,
Scott T. Kerridge,
Jonathan M. G. Higgins,
Owen R. Davies,
Suzanne Madgwick

Affiliations

Christopher Thomas: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Benjamin Wetherall: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Mark D. Levasseur: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Rebecca J. Harris: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Scott T. Kerridge: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Jonathan M. G. Higgins: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Owen R. Davies: Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Suzanne Madgwick: Biosciences Institute, Faculty of Medical Sciences, Newcastle University

DOI: https://doi.org/10.1038/s41467-021-24554-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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