Communications Biology (Aug 2022)

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer

  • Edward R. Polanco,
  • Tarek E. Moustafa,
  • Andrew Butterfield,
  • Sandra D. Scherer,
  • Emilio Cortes-Sanchez,
  • Tyler Bodily,
  • Benjamin T. Spike,
  • Bryan E. Welm,
  • Philip S. Bernard,
  • Thomas A. Zangle

DOI
https://doi.org/10.1038/s42003-022-03759-1
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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The authors developed a real-time and label-free approach based on quantitative phase imaging to determine drug sensitivity with significant advantages over endpoint viability or metabolic assays, and which reveals single cell response heterogeneity.