Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Xia Shen; Lucija Klarić; Sodbo Sharapov; Massimo Mangino; Zheng Ning; Di Wu; Irena Trbojević-Akmačić; Maja Pučić-Baković; Igor Rudan; Ozren Polašek; Caroline Hayward; Timothy D. Spector; James F. Wilson; Gordan Lauc; Yurii S. Aulchenko

doi:10.1038/s41467-017-00453-3

Nature Communications (Sep 2017)

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Xia Shen,
Lucija Klarić,
Sodbo Sharapov,
Massimo Mangino,
Zheng Ning,
Di Wu,
Irena Trbojević-Akmačić,
Maja Pučić-Baković,
Igor Rudan,
Ozren Polašek,
Caroline Hayward,
Timothy D. Spector,
James F. Wilson,
Gordan Lauc,
Yurii S. Aulchenko

Affiliations

Xia Shen: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Lucija Klarić: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Sodbo Sharapov: Novosibirsk State University
Massimo Mangino: Department for Twin Research, King’s College London
Zheng Ning: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
Di Wu: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
Irena Trbojević-Akmačić: Genos Glycoscience Research Laboratory
Maja Pučić-Baković: Genos Glycoscience Research Laboratory
Igor Rudan: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Ozren Polašek: Faculty of Medicine, University of Split
Caroline Hayward: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
Timothy D. Spector: Department for Twin Research, King’s College London
James F. Wilson: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Gordan Lauc: Genos Glycoscience Research Laboratory
Yurii S. Aulchenko: Novosibirsk State University

DOI: https://doi.org/10.1038/s41467-017-00453-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Multivariate analysis methods can uncover the relationship between phenotypic measures characterised by modern omic techniques. Here the authors conduct a multivariate GWAS on IgG N-glycosylation phenotypes and identify 5 novel loci enriched in immune system genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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