Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

Alessio Terenzi; Mery La Franca; Sushilla van Schoonhoven; Rostyslav Panchuk; Álvaro Martínez; Petra Heffeter; Redding Gober; Christine Pirker; Petra Vician; Christian R. Kowol; Rostyslav Stoika; Luca Salassa; Jürgen Rohr; Walter Berger

doi:10.1038/s42004-021-00600-4

Communications Chemistry (Nov 2021)

Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

Alessio Terenzi,
Mery La Franca,
Sushilla van Schoonhoven,
Rostyslav Panchuk,
Álvaro Martínez,
Petra Heffeter,
Redding Gober,
Christine Pirker,
Petra Vician,
Christian R. Kowol,
Rostyslav Stoika,
Luca Salassa,
Jürgen Rohr,
Walter Berger

Affiliations

Alessio Terenzi: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo
Mery La Franca: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo
Sushilla van Schoonhoven: Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna
Rostyslav Panchuk: Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology
Álvaro Martínez: Donostia International Physics Center and Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia, Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV/EHU
Petra Heffeter: Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna
Redding Gober: College of Pharmacy, University of Kentucky
Christine Pirker: Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna
Petra Vician: Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna
Christian R. Kowol: Research Cluster “Translational Cancer Therapy Research”, University of Vienna and Medical University of Vienna
Rostyslav Stoika: Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology
Luca Salassa: Donostia International Physics Center and Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia, Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV/EHU
Jürgen Rohr: College of Pharmacy, University of Kentucky
Walter Berger: Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna

DOI: https://doi.org/10.1038/s42004-021-00600-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Landomycins are promising anti-cancer agents with the potential to bypass common resistance pathways, but their mechanism of action remains incompletely understood. Here a mechanism is proposed involving intracellular sequential thiol-Michael and oxidation reactions, which depletes endogenous thiols and induces reactive oxygen species formation.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

About the journal