Nature Communications (Mar 2023)
Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring
Abstract
Anti-folate drugs, such as methotrexate, have been largely prohibited for pregnant women because of the teratogenic effect on their descendant. Here, the authors report a intergenerational mechanism by why paternal methotrexate exposure causes craniofacial defects on their offspring.