A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

Ying Fu; Zhen Zhang; Jared Sheehan; Yuval Avnir; Callie Ridenour; Thomas Sachnik; Jiusong Sun; M. Jaber Hossain; Li-Mei Chen; Quan Zhu; Ruben O. Donis; Wayne A. Marasco

doi:10.1038/ncomms12780

Nature Communications (Sep 2016)

A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

Ying Fu,
Zhen Zhang,
Jared Sheehan,
Yuval Avnir,
Callie Ridenour,
Thomas Sachnik,
Jiusong Sun,
M. Jaber Hossain,
Li-Mei Chen,
Quan Zhu,
Ruben O. Donis,
Wayne A. Marasco

Affiliations

Ying Fu: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
Zhen Zhang: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
Jared Sheehan: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
Yuval Avnir: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
Callie Ridenour: Influenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases
Thomas Sachnik: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
Jiusong Sun: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
M. Jaber Hossain: Influenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases
Li-Mei Chen: Influenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases
Quan Zhu: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
Ruben O. Donis: Influenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases
Wayne A. Marasco: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School

DOI: https://doi.org/10.1038/ncomms12780
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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