Glucagon-like peptide 1 receptor agonists and thyroid cancer: is it the time to be concerned?

Giuseppe Lisco; Anna De Tullio; Olga Disoteo; Giuseppina Piazzolla; Edoardo Guastamacchia; Carlo Sabbà; Vincenzo De Geronimo; Enrico Papini; Vincenzo Triggiani

doi:10.1530/EC-23-0257

Endocrine Connections (Oct 2023)

Glucagon-like peptide 1 receptor agonists and thyroid cancer: is it the time to be concerned?

Giuseppe Lisco,
Anna De Tullio,
Olga Disoteo,
Giuseppina Piazzolla,
Edoardo Guastamacchia,
Carlo Sabbà,
Vincenzo De Geronimo,
Enrico Papini,
Vincenzo Triggiani

Affiliations

Giuseppe Lisco: Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
Anna De Tullio: Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
Olga Disoteo: Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
Giuseppina Piazzolla: Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
Edoardo Guastamacchia: Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
Carlo Sabbà: Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
Vincenzo De Geronimo: Unit of Endocrinology, Policlinico Morgagni CCD, Catania, Italy
Enrico Papini: Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy
Vincenzo Triggiani: Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

DOI: https://doi.org/10.1530/EC-23-0257
Journal volume & issue: Vol. 12, no. 11
pp. 1 – 7

Abstract

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Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have changed considerably the management of type 2 diabetes (T2D). However, recently published data from retrospective cohort studies suggest that chronic exposure to GLP-1RAs in T2D may increase the risk of papillary and medullary thyroid cancer. In this perspective, the role of the incretin system in thyroid carcinogenesis has been reviewed and critically commented on, aiming to understand if the time has arrived to be concerned about the risk. Although evidence suggested, speculative hypotheses should be verified, and further studies are urgently needed to clarify the issue.

Published in Endocrine Connections

ISSN: 2049-3614 (Online)
Publisher: Bioscientifica
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: http://www.endocrineconnections.com/

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Abstract

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