Expression of FMRP in cutaneous malignant melanoma and its correlation with hematologic ratios

Abstract

Objective To investigate the expression of fragile X mental retardation protein (FMRP) in Chinese patients with malignant melanoma and its correlation with hematologic ratios. Methods Lesional skin samples were collected from 23 Chinese with malignant melanoma (melanoma group), and skin samples from 10 normal subjects served as controls (normal skin group). The expression of FMRP was observed using immunohistochemical(IHC) staining, and two scoring methods (H-Score and IRS) were used to evaluate the expression levels. The relationship between FMRP and different pathological grades and stages of malignant melanoma was assessed. The association of FMRP with some hematological ratios, such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and systemic inflammatory markers (SIM) in patients with malignant melanoma were analyzed. Results The expression levels of FMRP in the melanoma were significantly higher than that in the normal skin (P0.05). Expression levels of FMRP were positively correlated with NLR and SIM, while negatively correlated with LMR. Conclusions FMRP is highly expressed in cutaneous malignant melanoma and its expression levels are significantly correlated with NLR, SIM, and LMR.

Keywords

• cutaneous tumor
• malignant melanoma
• fragile x mental retardation protein