MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis

Stefano Alivernini; Elisa Gremese; Charles McSharry; Barbara Tolusso; Gianfranco Ferraccioli; Iain B. McInnes; Iain B. McInnes; Mariola Kurowska-Stolarska; Mariola Kurowska-Stolarska

doi:10.3389/fimmu.2017.01932

Frontiers in Immunology (Jan 2018)

MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis

Stefano Alivernini,
Elisa Gremese,
Charles McSharry,
Barbara Tolusso,
Gianfranco Ferraccioli,
Iain B. McInnes,
Iain B. McInnes,
Mariola Kurowska-Stolarska,
Mariola Kurowska-Stolarska

Affiliations

Stefano Alivernini: Institute of Rheumatology – Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy
Elisa Gremese: Institute of Rheumatology – Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy
Charles McSharry: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Barbara Tolusso: Institute of Rheumatology – Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy
Gianfranco Ferraccioli: Institute of Rheumatology – Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy
Iain B. McInnes: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Iain B. McInnes: Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Glasgow, United Kingdom
Mariola Kurowska-Stolarska: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Mariola Kurowska-Stolarska: Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Glasgow, United Kingdom

DOI: https://doi.org/10.3389/fimmu.2017.01932
Journal volume & issue: Vol. 8

Abstract

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MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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