Nature Communications (May 2020)

Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues

  • Andrew R. Marderstein,
  • Manik Uppal,
  • Akanksha Verma,
  • Bhavneet Bhinder,
  • Zakieh Tayyebi,
  • Jason Mezey,
  • Andrew G. Clark,
  • Olivier Elemento

DOI
https://doi.org/10.1038/s41467-020-16097-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Immune infiltration provides critical information for health and disease, yet it is unclear what factors influence infiltration levels. Here, the authors analyze human tissue transcriptomes from the Genotype-Tissue Expression project to find infiltration patterns regulated by age, sex and host genetic information.