A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification

B. Edginton-White; A. Maytum; S. G. Kellaway; D. K. Goode; P. Keane; I. Pagnuco; S. A. Assi; L. Ames; M. Clarke; P. N. Cockerill; B. Göttgens; J. B. Cazier; C. Bonifer

doi:10.1038/s41467-023-35910-9

Nature Communications (Jan 2023)

A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification

B. Edginton-White,
A. Maytum,
S. G. Kellaway,
D. K. Goode,
P. Keane,
I. Pagnuco,
S. A. Assi,
L. Ames,
M. Clarke,
P. N. Cockerill,
B. Göttgens,
J. B. Cazier,
C. Bonifer

Affiliations

B. Edginton-White: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
A. Maytum: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
S. G. Kellaway: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
D. K. Goode: Department of Haematology, Wellcome and Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge
P. Keane: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
I. Pagnuco: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
S. A. Assi: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
L. Ames: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
M. Clarke: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
P. N. Cockerill: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
B. Göttgens: Department of Haematology, Wellcome and Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge
J. B. Cazier: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham
C. Bonifer: Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham

DOI: https://doi.org/10.1038/s41467-023-35910-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

Read online

Defining cis-regulatory elements is an important goal in understanding how gene expression is regulated. Here the authors show blood cell-specific gene expression is controlled by the action of thousands of differentiation stage-specific sets of cis-elements that respond to cytokine signals terminating at signaling responsive transcription factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal