Nature Communications (Apr 2022)

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

  • Shu Shien Chin,
  • Erik Guillen,
  • Laurent Chorro,
  • Sooraj Achar,
  • Karina Ng,
  • Susanne Oberle,
  • Francesca Alfei,
  • Dietmar Zehn,
  • Grégoire Altan-Bonnet,
  • Fabien Delahaye,
  • Grégoire Lauvau

DOI
https://doi.org/10.1038/s41467-022-29718-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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The strength and duration of interleukin-2 (IL-2) signals is known to regulate T cell memory. Here the authors show that T cell receptor signalling strength controls the requirement for IL-2 signals to form CD8+ T cell memory with high functional activity and a wide range of genes with open chromatin regions.