Membranous nephropathy in chronic lymphocytic leukemia responsive to ibrutinib: A case report

Abstract

Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment involving alkylating agents and fludarabine. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.

Keywords

• Case report
• Membranous nephropathy
• Chronic lymphocytic leukemia
• Bruton tyrosine kinase
• Paraneoplastic