International Journal of General Medicine (Aug 2024)

Triglyceride–Glucose Index (TyG Index) in Association with Blood Pressure in Adults: A Retrospective Study

  • Aljuraiban GS,
  • Alharbi FJ,
  • Aljohi AO,
  • Almeshari AZ,
  • Al-Musharraf SI,
  • Aldhwayan MM,
  • Alshaikh F,
  • Abulmeaty M

Journal volume & issue
Vol. Volume 17
pp. 3395 – 3402

Abstract

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Ghadeer S Aljuraiban,1 Fahad J Alharbi,2 Ali O Aljohi,2 Abdullah Z Almeshari,2 Sara Ibrahim Al-Musharraf,1 Madhawi M Aldhwayan,1 Fahdah Alshaikh,1 Mahmoud Abulmeaty1 1Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11362, Saudi Arabia; 2Department of Central Military Laboratory & Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi ArabiaCorrespondence: Ghadeer S Aljuraiban, Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11362, Saudi Arabia, Email [email protected]: High blood pressure (BP) is a major risk factor for cardiovascular disease. The triglyceride-glucose (TyG) index is a useful tool for identifying insulin resistance at an early stage and has been proposed as a cost-effective predictor for hypertension. However, available studies are limited. This study aims to investigate the association between the TyG index and BP.Methods: Retrospective hospital data of a large cohort (n=1596) of adults aged ≥ 18 in Saudi Arabia were analyzed. The TyG index was calculated. Lipid markers, systolic BP (SBP), diastolic BP (DBP), and body mass index (BMI) were included.Results: Across quartiles of the TyG index, SBP was significantly higher in those with higher vs lower TyG (p< 0.03). No significant association was observed for DBP. A 2-SD higher SBP was significantly associated with a TyG difference of 1.7 (95% CI: 0.1, 3.3). In subgroup analysis, the relationship prevailed in females only [1.8 (95% CI: 0.3, 3.3)]. Across BMI categories (normal, overweight, obesity), the association between SBP and TyG was observed in participants with obesity only.Conclusions: The TyG index may act as a cost-effective predictive marker for high blood pressure, especially among specific subgroups. Future prospective studies are needed to confirm this relationship.Keywords: triglyceride-glucose index, blood pressure, hypertension, hyperlipidemia, cardiovascular disease

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