Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples

• Valerie B. O’Donnell,
• Nils H. Schebb,
• Ginger L. Milne,
• Michael P. Murphy,
• Christopher P. Thomas,
• Dieter Steinhilber,
• Stacy L. Gelhaus,
• Hartmut Kühn,
• Michael H. Gelb,
• Per-Johan Jakobsson,
• Ian A. Blair,
• Robert C. Murphy,
• Bruce A. Freeman,
• Alan R. Brash,
• Garret A. FitzGerald

Affiliations

Valerie B. O’Donnell

Systems Immunity Research Institute, School of Medicine, Cardiff University

Nils H. Schebb

Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences University of Wuppertal

Ginger L. Milne

Division of Clinical Pharmacology, Vanderbilt University

Michael P. Murphy

Medical Research Council Mitochondrial Biology Unit, University of Cambridge

Christopher P. Thomas

School of Pharmacy and Pharmaceutical Sciences, Cardiff University

Dieter Steinhilber

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt

Stacy L. Gelhaus

Department of Pharmacology and Chemical Biology, University of Pittsburgh

Hartmut Kühn

Institute of Biochemistry, University Medicine Berlin – Charité

Michael H. Gelb

Department of Chemistry, University of Washington

Per-Johan Jakobsson

Rheumatology Unit, Dep. of Medicine, Solna, Karolinska Institutet & Karolinska University Hospital

Ian A. Blair

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania

Robert C. Murphy

Department of Pharmacology, University of Colorado Denver

Bruce A. Freeman

Department of Pharmacology and Chemical Biology, University of Pittsburgh

Alan R. Brash

Department of Pharmacology, Vanderbilt University

Garret A. FitzGerald

Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, University of Pennsylvania