Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes

Yunjung Choi; Hyunju Kim; Moonseok Choi; Eun-Jeong Yang; Toru Takumi; Hye-Sun Kim

Journal of Pharmacological Sciences (Mar 2019)

Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes

Yunjung Choi,
Hyunju Kim,
Moonseok Choi,
Eun-Jeong Yang,
Toru Takumi,
Hye-Sun Kim

Affiliations

Yunjung Choi: Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea
Hyunju Kim: Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea
Moonseok Choi: Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea
Eun-Jeong Yang: Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea
Toru Takumi: RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan
Hye-Sun Kim: Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Seoul National University Bundang Hospital, Seongnam, 463-707, South Korea; Neuroscience Research Institute, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Corresponding author. Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea. Fax: +82 2 741 8298.

Journal volume & issue: Vol. 139, no. 3
pp. 249 – 253

Abstract

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The duplication of human chromosome 15q11-13 is known to be associated with an estimated 1.1% of autism cases. Here, we investigated whether differentiation into neurons and astrocytes is altered in fetal neural stem cells (FNSCs) isolated from the mouse model of 15q11-13 duplication syndrome (patDp/+ mice). In patDp/+ mice-derived FNSCs, multipotency was maintained for a longer period, the population of neurons was downregulated, and that of astrocytes was upregulated significantly after differentiation induction. These results suggest that the dysregulation of FNSCs differentiation could affect cortical development and behavioral deficits in the early postnatal stage shown in the patDp/+ mice. Keywords: Autism spectrum disorder, Paternal 15q11-13 duplication, FNSCs differentiation

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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