Vaccines (Dec 2022)
Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report
- Jason D. Goldman,
- Kai Wang,
- Katharina Röltgen,
- Sandra C. A. Nielsen,
- Jared C. Roach,
- Samia N. Naccache,
- Fan Yang,
- Oliver F. Wirz,
- Kathryn E. Yost,
- Ji-Yeun Lee,
- Kelly Chun,
- Terri Wrin,
- Christos J. Petropoulos,
- Inyoul Lee,
- Shannon Fallen,
- Paula M. Manner,
- Julie A. Wallick,
- Heather A. Algren,
- Kim M. Murray,
- Jennifer Hadlock,
- Daniel Chen,
- Chengzhen L. Dai,
- Dan Yuan,
- Yapeng Su,
- Joshua Jeharajah,
- William R. Berrington,
- George P. Pappas,
- Sonam T. Nyatsatsang,
- Alexander L. Greninger,
- Ansuman T. Satpathy,
- John S. Pauk,
- Scott D. Boyd,
- James R. Heath
Affiliations
- Jason D. Goldman
- Division of Infectious Diseases, Swedish Medical Center, Seattle, WA 98122, USA
- Kai Wang
- Institute for Systems Biology, Seattle, WA 98103, USA
- Katharina Röltgen
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- Sandra C. A. Nielsen
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- Jared C. Roach
- Institute for Systems Biology, Seattle, WA 98103, USA
- Samia N. Naccache
- Department of Microbiology, LabCorp, Seattle, WA 98104, USA
- Fan Yang
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- Oliver F. Wirz
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- Kathryn E. Yost
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- Ji-Yeun Lee
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- Kelly Chun
- LabCorp Esoterix, Calabasas, CA 91301, USA
- Terri Wrin
- Monogram Biosciences, South San Francisco, CA 94080, USA
- Christos J. Petropoulos
- Monogram Biosciences, South San Francisco, CA 94080, USA
- Inyoul Lee
- Institute for Systems Biology, Seattle, WA 98103, USA
- Shannon Fallen
- Institute for Systems Biology, Seattle, WA 98103, USA
- Paula M. Manner
- Providence St. Joseph Health, Renton, WA 98057, USA
- Julie A. Wallick
- Providence St. Joseph Health, Renton, WA 98057, USA
- Heather A. Algren
- Providence St. Joseph Health, Renton, WA 98057, USA
- Kim M. Murray
- Institute for Systems Biology, Seattle, WA 98103, USA
- Jennifer Hadlock
- Providence St. Joseph Health, Renton, WA 98057, USA
- Daniel Chen
- Institute for Systems Biology, Seattle, WA 98103, USA
- Chengzhen L. Dai
- Institute for Systems Biology, Seattle, WA 98103, USA
- Dan Yuan
- Institute for Systems Biology, Seattle, WA 98103, USA
- Yapeng Su
- Institute for Systems Biology, Seattle, WA 98103, USA
- Joshua Jeharajah
- Division of Infectious Diseases, Polyclinic, Seattle, WA 98104, USA
- William R. Berrington
- Division of Infectious Diseases, Swedish Medical Center, Seattle, WA 98122, USA
- George P. Pappas
- Division of Pulmonology and Critical Care Medicine, Swedish Medical Center, Seattle, WA 98104, USA
- Sonam T. Nyatsatsang
- Division of Infectious Diseases, Swedish Medical Center, Seattle, WA 98122, USA
- Alexander L. Greninger
- Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA
- Ansuman T. Satpathy
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- John S. Pauk
- Division of Infectious Diseases, Swedish Medical Center, Seattle, WA 98122, USA
- Scott D. Boyd
- Department of Pathology, Stanford University, Stanford, CA 94305, USA
- James R. Heath
- Institute for Systems Biology, Seattle, WA 98103, USA
- DOI
- https://doi.org/10.3390/vaccines11010005
- Journal volume & issue
-
Vol. 11,
no. 1
p. 5
Abstract
Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.
Keywords
