Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Manuel D. Díaz-Muñoz; Vladimir Yu. Kiselev; Nicolas Le Novère; Tomaz Curk; Jernej Ule; Martin Turner

doi:10.1038/s41467-017-00454-2

Nature Communications (Sep 2017)

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Manuel D. Díaz-Muñoz,
Vladimir Yu. Kiselev,
Nicolas Le Novère,
Tomaz Curk,
Jernej Ule,
Martin Turner

Affiliations

Manuel D. Díaz-Muñoz: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute
Vladimir Yu. Kiselev: Laboratory of Signalling, The Babraham Institute
Nicolas Le Novère: Laboratory of Signalling, The Babraham Institute
Tomaz Curk: University of Ljubljana, Faculty of Computer and Information Science
Jernej Ule: Department of Molecular Neuroscience, UCL Institute of Neurology
Martin Turner: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute

DOI: https://doi.org/10.1038/s41467-017-00454-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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