Nature Communications (Aug 2021)
Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
- Gu-Lung Lin,
- Simon B. Drysdale,
- Matthew D. Snape,
- Daniel O’Connor,
- Anthony Brown,
- George MacIntyre-Cockett,
- Esther Mellado-Gomez,
- Mariateresa de Cesare,
- David Bonsall,
- M. Azim Ansari,
- Deniz Öner,
- Jeroen Aerssens,
- Christopher Butler,
- Louis Bont,
- Peter Openshaw,
- Federico Martinón-Torres,
- Harish Nair,
- Rory Bowden,
- RESCEU Investigators,
- Tanya Golubchik,
- Andrew J. Pollard
Affiliations
- Gu-Lung Lin
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Simon B. Drysdale
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Matthew D. Snape
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Daniel O’Connor
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Anthony Brown
- Peter Medawar Building for Pathogen Research, University of Oxford
- George MacIntyre-Cockett
- Wellcome Centre for Human Genetics, University of Oxford
- Esther Mellado-Gomez
- Wellcome Centre for Human Genetics, University of Oxford
- Mariateresa de Cesare
- Wellcome Centre for Human Genetics, University of Oxford
- David Bonsall
- Wellcome Centre for Human Genetics, University of Oxford
- M. Azim Ansari
- Wellcome Centre for Human Genetics, University of Oxford
- Deniz Öner
- Translational Biomarkers, Infectious Diseases Therapeutic Area, Janssen Pharmaceutica NV
- Jeroen Aerssens
- Translational Biomarkers, Infectious Diseases Therapeutic Area, Janssen Pharmaceutica NV
- Christopher Butler
- Nuffield Department of Primary Care Health Sciences, University of Oxford
- Louis Bont
- Department of Pediatrics, Wilhelmina Children’s Hospital, University Medical Center Utrecht
- Peter Openshaw
- National Heart and Lung Institute, Imperial College London
- Federico Martinón-Torres
- Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela
- Harish Nair
- Centre for Global Health, Usher Institute, Edinburgh Medical School, University of Edinburgh
- Rory Bowden
- Wellcome Centre for Human Genetics, University of Oxford
- RESCEU Investigators
- Tanya Golubchik
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Andrew J. Pollard
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-021-25265-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Respiratory syncytial virus (RSV) is a common infection in children and older adults but little is known about within-host viral population diversity. Here, the authors perform deep sequencing and find that RSV subgroup B exhibited more diversity than subgroup A, with implications for development of therapeutics and vaccines.
