The research progress of Gli1 in the regulation of epithelial mesenchymal transition in oral squamous cell car⁃ cinoma

Abstract

HH (hedgehog) signal pathway consists the hedgehoge ligand (Shh、Ihh and Dhh), the Patch and Smo membrane protein complex and Zinc finger transcription factor Gli (Gli1, Gli2, Gli3). In HH (hedgehog) signaling path⁃ way, Gli1 not only plays a dominant and decisive role in the zinc finger transcription factor Gli (Glioma⁃associated onco⁃ gene homolog) family, but also includes epithelial⁃mesenchymal transition (EMT) and oral squamous cell carcinoma, tu⁃ mor invasion and metastasis. The research on oral squamous cell carcinoma and Shh/Gli1 signal axis is rare. In this pa⁃ per, the squamous cell carcinoma of oral epithelial mesenchymal transformation and correlation study of quality Gli1 is reviewed.

Keywords

• Gli1
• Epithelial⁃mesenchymal transition
• Hedgehog signaling pathway
• Oral squamous cell carcino⁃ ma
• Tumor metastasis suppressor