Nature Communications (Oct 2017)
YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
- Wenyi Mi,
- Haipeng Guan,
- Jie Lyu,
- Dan Zhao,
- Yuanxin Xi,
- Shiming Jiang,
- Forest H. Andrews,
- Xiaolu Wang,
- Mihai Gagea,
- Hong Wen,
- Laszlo Tora,
- Sharon Y. R. Dent,
- Tatiana G. Kutateladze,
- Wei Li,
- Haitao Li,
- Xiaobing Shi
Affiliations
- Wenyi Mi
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center
- Haipeng Guan
- MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University
- Jie Lyu
- Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine
- Dan Zhao
- MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University
- Yuanxin Xi
- Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine
- Shiming Jiang
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center
- Forest H. Andrews
- Department of Pharmacology, University of Colorado School of Medicine
- Xiaolu Wang
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center
- Mihai Gagea
- Department of Veterinary Medicine & Surgery, The University of Texas M.D. Anderson Cancer Center
- Hong Wen
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center
- Laszlo Tora
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- Sharon Y. R. Dent
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center
- Tatiana G. Kutateladze
- Department of Pharmacology, University of Colorado School of Medicine
- Wei Li
- Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine
- Haitao Li
- MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University
- Xiaobing Shi
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-017-01173-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Histone modification recognition is an important mechanism for gene expression regulation in cancer. Here, the authors identify YEATS2 as a histone H3K27ac reader, regulating a transcriptional program essential for tumorigenesis in human non-small cell lung cancer.
