Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow

Sarah M. Friedrich; Jeffrey M. Burke; Kelvin J. Liu; Cornelius F. Ivory; Tza-Huei Wang

doi:10.1038/s41467-017-01214-y

Nature Communications (Oct 2017)

Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow

Sarah M. Friedrich,
Jeffrey M. Burke,
Kelvin J. Liu,
Cornelius F. Ivory,
Tza-Huei Wang

Affiliations

Sarah M. Friedrich: Biomedical Engineering Department, Johns Hopkins University
Jeffrey M. Burke: Circulomics, Inc.
Kelvin J. Liu: Circulomics, Inc.
Cornelius F. Ivory: Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University
Tza-Huei Wang: Biomedical Engineering Department, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-017-01214-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Implementing a nucleic acid preconcentration method can improve the sensitivity of microfluidic analysis systems. Here Friedrich et al. concentrate DNA by many orders of magnitude using pressure-driven flow, which could lead to a simple and practical microanalysis platform.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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