Nature Communications (Nov 2017)
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
- Lesley-Ann Martin,
- Ricardo Ribas,
- Nikiana Simigdala,
- Eugene Schuster,
- Sunil Pancholi,
- Tencho Tenev,
- Pascal Gellert,
- Laki Buluwela,
- Alison Harrod,
- Allan Thornhill,
- Joanna Nikitorowicz-Buniak,
- Amandeep Bhamra,
- Marc-Olivier Turgeon,
- George Poulogiannis,
- Qiong Gao,
- Vera Martins,
- Margaret Hills,
- Isaac Garcia-Murillas,
- Charlotte Fribbens,
- Neill Patani,
- Zheqi Li,
- Matthew J. Sikora,
- Nicholas Turner,
- Wilbert Zwart,
- Steffi Oesterreich,
- Jason Carroll,
- Simak Ali,
- Mitch Dowsett
Affiliations
- Lesley-Ann Martin
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Ricardo Ribas
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Nikiana Simigdala
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Eugene Schuster
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Sunil Pancholi
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Tencho Tenev
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Pascal Gellert
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Laki Buluwela
- Division of Cancer, CRUK Labs, University of London Imperial College
- Alison Harrod
- Division of Cancer, CRUK Labs, University of London Imperial College
- Allan Thornhill
- Centre for Cancer Imaging, Institute of Cancer Research
- Joanna Nikitorowicz-Buniak
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Amandeep Bhamra
- Proteomic Unit, Institute of Cancer Research
- Marc-Olivier Turgeon
- Division of Cancer Biology, The Institute of Cancer Research
- George Poulogiannis
- Division of Cancer Biology, The Institute of Cancer Research
- Qiong Gao
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Vera Martins
- Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital
- Margaret Hills
- Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital
- Isaac Garcia-Murillas
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Charlotte Fribbens
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Neill Patani
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Zheqi Li
- Department of Pharmacology and Chemical biology, University of Pittsburgh
- Matthew J. Sikora
- Department of Pharmacology and Chemical biology, University of Pittsburgh
- Nicholas Turner
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Wilbert Zwart
- Department of Molecular Pathology, Netherlands Cancer Institute
- Steffi Oesterreich
- Department of Pharmacology and Chemical biology, University of Pittsburgh
- Jason Carroll
- Cancer Research UK Cambridge Institute, University of Cambridge
- Simak Ali
- Division of Cancer, CRUK Labs, University of London Imperial College
- Mitch Dowsett
- Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-017-01864-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
ESR1 mutations occur in endocrine-resistant patients but have not yet been reported in in vitro models of breast cancer. Here, the authors report the discovery of naturally occurring ESR1 Y537Cand ESR1 Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estrogen-deprivation.
