Nature Communications (Jul 2018)
CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection
- Vishal Khairnar,
- Vikas Duhan,
- Ashwini M. Patil,
- Fan Zhou,
- Hilal Bhat,
- Christine Thoens,
- Piyush Sharma,
- Tom Adomati,
- Sarah-Kim Friendrich,
- Judith Bezgovsek,
- Janine D. Dreesen,
- Gunther Wennemuth,
- Astrid M. Westendorf,
- Gennadiy Zelinskyy,
- Ulf Dittmer,
- Cornelia Hardt,
- Jörg Timm,
- Joachim R. Göthert,
- Philipp A. Lang,
- Bernhard B. Singer,
- Karl S. Lang
Affiliations
- Vishal Khairnar
- Institute of Immunology, University Hospital Essen
- Vikas Duhan
- Institute of Immunology, University Hospital Essen
- Ashwini M. Patil
- Department of Hematology, West German Cancer Center (WTZ), University Hospital Essen
- Fan Zhou
- Institute of Immunology, University Hospital Essen
- Hilal Bhat
- Institute of Immunology, University Hospital Essen
- Christine Thoens
- Institute of Virology, Medical Faculty, Heinrich-Heine-University
- Piyush Sharma
- Institute of Immunology, University Hospital Essen
- Tom Adomati
- Institute of Immunology, University Hospital Essen
- Sarah-Kim Friendrich
- Institute of Immunology, University Hospital Essen
- Judith Bezgovsek
- Institute of Immunology, University Hospital Essen
- Janine D. Dreesen
- Institute of Anatomy, Medical Faculty, University Hospital Essen
- Gunther Wennemuth
- Institute of Anatomy, Medical Faculty, University Hospital Essen
- Astrid M. Westendorf
- Institute of Medical Microbiology, Faculty of Medicine, University Hospital Essen
- Gennadiy Zelinskyy
- Institute for Virology, University Hospital Essen
- Ulf Dittmer
- Institute for Virology, University Hospital Essen
- Cornelia Hardt
- Institute of Immunology, University Hospital Essen
- Jörg Timm
- Institute of Virology, Medical Faculty, Heinrich-Heine-University
- Joachim R. Göthert
- Department of Hematology, West German Cancer Center (WTZ), University Hospital Essen
- Philipp A. Lang
- Clinic of Gastroenterology, Hepatology and Infectious Disease, Heinrich-Heine-University
- Bernhard B. Singer
- Institute of Anatomy, Medical Faculty, University Hospital Essen
- Karl S. Lang
- Institute of Immunology, University Hospital Essen
- DOI
- https://doi.org/10.1038/s41467-018-04832-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Chronic viral infections are frequently associated with the dysfunction of CD8+ T cells which includes loss of function and results in CD8+ T cell exhaustion. Here the authors show a role of CEACAM1 in promoting responsive CD8+ T cells in the context of a chronic lymphocytic choriomeningitis virus (LCMV) infection model.
