Frontiers in Medicine (Feb 2023)

Myocardial infarction or myocarditis? A case report and review of a myocardial adverse event associated with mRNA vaccine

  • Roberto Badaró,
  • Roberto Badaró,
  • Gustavo Novaes,
  • Ana Cristina Andrade,
  • Cesar Augusto de Araujo Neto,
  • Bruna Aparecida Machado,
  • Josiane Dantas Viana Barbosa,
  • Milena Botelho Pereira Soares,
  • Milena Botelho Pereira Soares

DOI
https://doi.org/10.3389/fmed.2023.1071239
Journal volume & issue
Vol. 10

Abstract

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A 23-year-old man started with chest pain 8 h after his first Pfizer-BioNTech COVID-19 vaccination. ECG evaluation showed sinus tachycardia with ST-segment elevation in D1, AVL, V5, and V6, the findings compatible with acute subepicardial myocardial damage. However, cardiac MRI documented myocardial fibrosis, with cardiac late enhancement non-ischemic pattern with diffuse edema. He had no other symptoms to suggest another etiology than the vaccination. The patient was hospitalized and received corticosteroid (prednisolone) daily. Then, 2 weeks after hospitalization, all laboratory parameters and ECG were normal and the patient was discharged from the hospital. The patient had a history of Wolf-Parkinson White that was corrected with ablation when he was 11 years old. This report calls attention to myocardial adverse reaction risk for mRNA COVID-19 vaccines for people with a previous cardiac disease history.

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