Immunity & Ageing (Apr 2023)

Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation

  • Kaiwu He,
  • Lulin Nie,
  • Tahir Ali,
  • Zizhen Liu,
  • Weifen Li,
  • Ruyan Gao,
  • Zena Zhang,
  • Jianjun Liu,
  • Zhongliang Dai,
  • Yongmei Xie,
  • Zaijun Zhang,
  • Gongping Liu,
  • Ming Dong,
  • Zhi-Jian Yu,
  • Shupeng Li,
  • Xifei Yang

DOI
https://doi.org/10.1186/s12979-023-00339-7
Journal volume & issue
Vol. 20, no. 1
pp. 1 – 13

Abstract

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Abstract Background A wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by mitochondria dysfunction is one of the significant factors associated with age. Adiponectin (APN), an essential adipokine in glucose and lipid metabolism, is involved in the aging; however, its role in brain aging has not been adequately explored. Here, we aimed to explore the relationship between APN deficiency and brain aging using multiple biochemical and pharmacological methods to probe APN in humans, KO mice, primary microglia, and BV2 cells. Results We found that declining APN levels in aged human subjects correlated with dysregulated cytokine levels, while APN KO mice exhibited accelerated aging accompanied by learning and memory deficits, anxiety-like behaviors, neuroinflammation, and immunosenescence. APN-deficient mice displayed aggravated mitochondrial dysfunction and HDAC1 upregulation. In BV2 cells, the APN receptor agonist AdipoRon alleviated the mitochondrial deficits and aging markers induced by rotenone or antimycin A. HDAC1 antagonism by Compound 60 (Cpd 60) improved mitochondrial dysfunction and age-related inflammation, as validated in D-galactose-treated APN KO mice. Conclusion These findings indicate that APN is a critical regulator of brain aging by preventing neuroinflammation associated with mitochondrial impairment via HDAC1 signaling.

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