Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells

• Kevin R. Zhang,
• Connor S. R. Jankowski,
• Rayna Marshall,
• Rohini Nair,
• Néstor Más Gómez,
• Ahab Alnemri,
• Yingrui Liu,
• Elizabeth Erler,
• Julia Ferrante,
• Ying Song,
• Brent A. Bell,
• Bailey H. Baumann,
• Jacob Sterling,
• Brandon Anderson,
• Sierra Foshe,
• Jennifer Roof,
• Hossein Fazelinia,
• Lynn A. Spruce,
• Jen-Zen Chuang,
• Ching-Hwa Sung,
• Anuradha Dhingra,
• Kathleen Boesze-Battaglia,
• Venkata R. M. Chavali,
• Joshua D. Rabinowitz,
• Claire H. Mitchell,
• Joshua L. Dunaief

Affiliations

Kevin R. Zhang

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Connor S. R. Jankowski

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA

Rayna Marshall

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Rohini Nair

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Néstor Más Gómez

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Ahab Alnemri

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Yingrui Liu

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Elizabeth Erler

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Julia Ferrante

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Ying Song

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Brent A. Bell

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Bailey H. Baumann

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Jacob Sterling

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Brandon Anderson

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Sierra Foshe

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Jennifer Roof

CHOP-PENN Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA

Hossein Fazelinia

CHOP-PENN Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA

Lynn A. Spruce

CHOP-PENN Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA

Jen-Zen Chuang

Department of Ophthalmology, Weill Cornell Medicine, New York, NY 10065, USA

Ching-Hwa Sung

Department of Ophthalmology, Weill Cornell Medicine, New York, NY 10065, USA

Anuradha Dhingra

Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Kathleen Boesze-Battaglia

Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Venkata R. M. Chavali

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Joshua D. Rabinowitz

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA

Claire H. Mitchell

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

Joshua L. Dunaief

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA