Annals of Clinical and Translational Neurology (Aug 2024)

DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease

  • Viviana Torres,
  • Jesica Pérez‐Montesino,
  • Rubén Fernández‐Santiago,
  • Manel Fernández,
  • Ana Camara,
  • Yaroslau Compta,
  • María‐José Martí,
  • Àlex Guerra Beltran,
  • José Rios,
  • Francesc Valldeoriola,
  • Mario Ezquerra

DOI
https://doi.org/10.1002/acn3.52111
Journal volume & issue
Vol. 11, no. 8
pp. 2222 – 2229

Abstract

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Abstract Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.