Design of a temperature-feedback controlled automated magnetic hyperthermia therapy device

Anirudh Sharma; Avesh Avinash Jangam; Julian Low Yung Shen; Aiman Ahmad; Nageshwar Arepally; Hayden Carlton; Robert Ivkov; Robert Ivkov; Robert Ivkov; Anilchandra Attaluri

doi:10.3389/fther.2023.1131262

Frontiers in Thermal Engineering (Feb 2023)

Design of a temperature-feedback controlled automated magnetic hyperthermia therapy device

Anirudh Sharma,
Avesh Avinash Jangam,
Julian Low Yung Shen,
Aiman Ahmad,
Nageshwar Arepally,
Hayden Carlton,
Robert Ivkov,
Robert Ivkov,
Robert Ivkov,
Anilchandra Attaluri

Affiliations

Anirudh Sharma: Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Avesh Avinash Jangam: Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University—Harrisburg, Middletown, PA, United States
Julian Low Yung Shen: Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University—Harrisburg, Middletown, PA, United States
Aiman Ahmad: Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University—Harrisburg, Middletown, PA, United States
Nageshwar Arepally: Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University—Harrisburg, Middletown, PA, United States
Hayden Carlton: Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Robert Ivkov: Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Robert Ivkov: Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States
Robert Ivkov: Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States
Anilchandra Attaluri: Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University—Harrisburg, Middletown, PA, United States

DOI: https://doi.org/10.3389/fther.2023.1131262
Journal volume & issue: Vol. 3

Abstract

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Introduction: Magnetic hyperthermia therapy (MHT) is a minimally invasive adjuvant therapy capable of damaging tumors using magnetic nanoparticles exposed radiofrequency alternating magnetic fields. One of the challenges of MHT is thermal dose control and excessive heating in superficial tissues from off target eddy current heating.Methods: We report the development of a control system to maintain target temperature during MHT with an automatic safety shutoff feature in adherence to FDA Design Control Guidance. A proportional-integral-derivative (PID) control algorithm was designed and implemented in NI LabVIEW®. A standard reference material copper wire was used as the heat source to verify the controller performance in gel phantom experiments. Coupled electromagnetic thermal finite element analysis simulations were used to identify the initial controller gains.Results: Results showed that the PID controller successfully achieved the target temperature control despite significant perturbations.Discussion and Conclusion: Feasibility of PID control algorithm to improve efficacy and safety of MHT was demonstrated.

Published in Frontiers in Thermal Engineering

ISSN: 2813-0456 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General): Mechanics of engineering. Applied mechanics; Technology: Chemical technology: Fuel
Website: https://www.frontiersin.org/journals/thermal-engineering

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