Clinical implications of admission and follow-up urea-to-creatinine ratio in patients with acute decompensated heart failure

Abstract

Abstract Purpose Acute decompensated heart failure (ADHF) patients with a poor renal function have a worse prognosis. The urea-to-creatinine ratio (UCR) may be a valuable tool for assessing kidney function and stratifying patients with ADHF. We evaluated the value of an admission and follow-up UCR in predicting AKI, 28-day mortality, and rehospitalization in patients with ADHF. Methods This prospective research comprised sixty patients with ADHF. Based on the mean admission UCR, patients are classified into two groups: the high UCR group (UCR ≥ 42.33) and the low UCR group (UCR 34.85 (p < 0.001). Conclusion The follow-up UCR is a good predictor of AKI development and elevated 28-day mortality in ADHF patients. Considering its simplicity, this biomarker should be used more systematically in clinical practice.

Keywords

• Urea-to-creatinine ratio
• Acute kidney injury
• 28-day mortality
• Rehospitalization
• Acute decompensated heart failure